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Gene TET2
Variant Q891fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TET2 Q891fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 891 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). Q891fs has not been characterized however, due to the effects of other truncation mutations downstream of Q891 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 inact mut TET2 Q891fs

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Transcript NM_001127208.3
gDNA chr4:g.(105236612_105236613)
cDNA c.(2671_2670)
Protein p.Q891fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127208.2 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_047415840.1 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_047415841.1 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_017008319.2 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_024454103.1 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_047415843.1 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_006714242.3 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
NM_017628.4 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_005263082.3 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_006714242.4 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_047415839.1 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_047415842.1 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_017008319.1 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38
NM_017628.4 chr4:g.(105236612_105236613) c.(2671_2670) p.Q891fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
TET2 Q891fs loss of function - predicted