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Gene PIK3CA
Variant R617W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA R617W lies within the PIK helical domain of the Pik3ca protein (UniProt.org). R617W has been identified in sequencing studies (PMID: 23765252, PMID: 22653804), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA R617W

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Transcript NM_006218.4
gDNA chr3:g.179219673C>T
cDNA c.1849C>T
Protein p.R617W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179219673C>T c.1849C>T p.R617W RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179219673C>T c.1849C>T p.R617W RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179219673C>T c.1849C>T p.R617W RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179219673C>T c.1849C>T p.R617W RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179219673C>T c.1849C>T p.R617W RefSeq GRCh38/hg38
XM_011512894 chr3:g.179219673C>T c.1849C>T p.R617W RefSeq GRCh38/hg38
XM_006713658 chr3:g.179219673C>T c.1849C>T p.R617W RefSeq GRCh38/hg38
NM_006218 chr3:g.179219673C>T c.1849C>T p.R617W RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References