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Gene PIK3CA
Variant T1025A
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA T1025A lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). T1025A results in increased transformation ability in two different cell lines in culture (PMID: 29533785), and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA T1025A

PIK3CA mutant PIK3CA exon21 PIK3CA T1025A

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Transcript NM_006218.4
gDNA chr3:g.179234230A>G
cDNA c.3073A>G
Protein p.T1025A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179234230A>G c.3073A>G p.T1025A RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179234230A>G c.3073A>G p.T1025A RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179234230A>G c.3073A>G p.T1025A RefSeq GRCh38/hg38
NM_006218 chr3:g.179234230A>G c.3073A>G p.T1025A RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179234230A>G c.3073A>G p.T1025A RefSeq GRCh38/hg38
XM_006713658 chr3:g.179234230A>G c.3073A>G p.T1025A RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179234230A>G c.3073A>G p.T1025A RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179234230A>G c.3073A>G p.T1025A RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries