HRAS R135A
Gene Variant Detail

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Gene HRAS
Variant R135A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions HRAS R135A does not lie within any known functional domains of the Hras protein (UniProt.org). R135A results in impaired GTP-HRAS downstream signaling when combined with R128A (PMID: 18273062), and is associated with resistance to NS1 (PMID: 27820802), but has not been fully biochemically characterized and therefore, its effect on Hras protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

HRAS mutant HRAS R135A

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Transcript NM_005343.4
gDNA chr11:g.533499_533500delCGinsGC
cDNA c.403_404delCGinsGC
Protein p.R135A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442.3 chr11:g.533499_533500delCGinsGC c.403_404delCGinsGC p.R135A RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533499_533500delCGinsGC c.403_404delCGinsGC p.R135A RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533499_533500delCGinsGC c.403_404delCGinsGC p.R135A RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533499_533500delCGinsGC c.403_404delCGinsGC p.R135A RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533499_533500delCGinsGC c.403_404delCGinsGC p.R135A RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533499_533500delCGinsGC c.403_404delCGinsGC p.R135A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
HRAS R135A unknown
HRAS G12V HRAS R135A