FBXW7 S668Vfs*39
Gene Variant Detail

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Gene FBXW7
Variant S668Vfs*39
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions FBXW7 S668Vfs*39 indicates a shift in the reading frame starting at amino acid 668 and terminating 39 residues downstream causing a premature truncation of the 707 amino acid Fbxw7 protein (UniProt.org). S668Vfs*39 has been identified in the scientific literature (J Thorac Oncol 13:10, 2018 (suppl; abstr S524)), but has not been biochemically characterized and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Jun 2025).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 S668fs FBXW7 S668Vfs*39

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Transcript NM_001349798.2
gDNA chr4:g.152323003delT
cDNA c.2002delA
Protein p.S668Vfs*39
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001349798.2 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152323003delT c.2002delA p.S668Vfs*39 RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References