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Gene DNMT3A
Variant I643M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions DNMT3A I643M lies within the SAM-dependent MTase C5-type domain of the Dnmt3a protein (UniProt.org). I643M has been identified in sequencing studies (PMID: 28634182), but has not been biochemically characterized and therefore, its effect on Dnmt3a protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A I643M

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Transcript NM_022552.5
gDNA chr2:g.25243905G>C
cDNA c.1929C>G
Protein p.I643M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005264175.6 chr2:g.25243905G>C c.1929C>G p.I643M RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25243905G>C c.1929C>G p.I643M RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25243905G>C c.1929C>G p.I643M RefSeq GRCh38/hg38
XM_011532664.3 chr2:g.25243905G>C c.1929C>G p.I643M RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.25243905G>C c.1929C>G p.I643M RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.25243905G>C c.1929C>G p.I643M RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25243905G>C c.1929C>G p.I643M RefSeq GRCh38/hg38
XM_011532664.2 chr2:g.25243905G>C c.1929C>G p.I643M RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25243905G>C c.1929C>G p.I643M RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25243905G>C c.1929C>G p.I643M RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25243905G>C c.1929C>G p.I643M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References