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Gene PIK3CA
Variant Y272*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions PIK3CA Y272* results in a premature truncation of the Pik3ca protein at amino acid 272 of 1068 (UniProt.org). Due to the loss of the PI3K/PI4K kinase domain (UniProt.org), Y272* is predicted to lead to a loss of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon5 PIK3CA Y272*

PIK3CA mutant PIK3CA inact mut PIK3CA Y272*

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Transcript NM_006218.4
gDNA chr3:g.179203546T>A
cDNA c.816T>A
Protein p.Y272*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179203546T>A c.816T>A p.Y272* RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179203546T>A c.816T>A p.Y272* RefSeq GRCh38/hg38
XM_006713658 chr3:g.179203546T>A c.816T>A p.Y272* RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179203546T>A c.816T>A p.Y272* RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179203546T>A c.816T>A p.Y272* RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179203546T>A c.816T>A p.Y272* RefSeq GRCh38/hg38
NM_006218 chr3:g.179203546T>A c.816T>A p.Y272* RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179203546T>A c.816T>A p.Y272* RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References