FGFR2 K41E - Gene Variant Detail

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Gene FGFR2
Variant K41E
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 K41E lies within Ig-like C2-type domain 1 of the Fgfr2 protein (UniProt.org). K41E results in decreased Fgfr2 expression, but demonstrates subcellular localization, basal and ligand-dependent Erk phosphorylation levels similar to wild-type Fgfr2 in culture (PMID: 30761385), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 K41E

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Transcript NM_000141.5
gDNA chr10:g.121565693T>C
cDNA c.121A>G
Protein p.K41E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144913.1 chr10:g.121565693T>C c.121A>G p.K41E RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121565693T>C c.121A>G p.K41E RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121565693T>C c.121A>G p.K41E RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121565693T>C c.121A>G p.K41E RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121565693T>C c.121A>G p.K41E RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121565693T>C c.121A>G p.K41E RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121565693T>C c.121A>G p.K41E RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121565693T>C c.121A>G p.K41E RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121565693T>C c.121A>G p.K41E RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121565693T>C c.121A>G p.K41E RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121565693T>C c.121A>G p.K41E RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121565693T>C c.121A>G p.K41E RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References