TP53 L137Q
Gene Variant Detail

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Gene TP53
Variant L137Q
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 L137Q lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). L137Q results in a loss of p21 induction and anti-proliferation response in culture, and the genomic change leads to aberrant splicing and reduced mRNA level (PMID: 39774325).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 L137Q

TP53 mutant TP53 inact mut TP53 L137Q

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Transcript NM_000546.6
gDNA chr17:g.7675202A>T
cDNA c.410T>A
Protein p.L137Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.3 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675202A>T c.410T>A p.L137Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References