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Gene FBXW7
Variant G579A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 G579A does not lie within any known functional domains of the Fbxw7 protein (UniProt.org). G579A has not been characterized in the scientific literature and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 G579A

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Transcript NM_033632.3
gDNA chr4:g.152324303C>G
cDNA c.1736G>C
Protein p.G579A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001349798.2 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152324303C>G c.1736G>C p.G579A RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FBXW7 mutant Her2-receptor negative breast cancer predicted - sensitive LY3039478 Case Reports/Case Series Actionable In a Phase I trial, LY3039478 treatment resulted in partial response lasted 9.5 months in a patient with hormone receptor-positive, Erbb2 (Her2)-negative breast cancer harboring FBXW7 mutation (PMID: 30060061; NCT01695005). 30060061