PIK3CA H419_C420del
Gene Variant Detail

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Gene PIK3CA
Variant H419_C420del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA H419_C420del results in the deletion of two amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 419 to 420 (UniProt.org). H419_C420del has been identified in sequencing studies (PMID: 30212483, PMID: 26051240, PMID: 26080840), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Feb 2026).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA H419_C420del

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Transcript NM_006218.4
gDNA chr3:g.179210190_179210195delACTGTC
cDNA c.1256_1261delACTGTC
Protein p.H419_C420delHC
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179210190_179210195delACTGTC c.1256_1261delACTGTC p.H419_C420del RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210190_179210195delACTGTC c.1256_1261delACTGTC p.H419_C420del RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210190_179210195delACTGTC c.1256_1261delACTGTC p.H419_C420del RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210190_179210195delACTGTC c.1256_1261delACTGTC p.H419_C420delHC RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210190_179210195delACTGTC c.1256_1261delACTGTC p.H419_C420delHC RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210190_179210195delACTGTC c.1256_1261delACTGTC p.H419_C420del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
PIK3CA H419_C420del unknown