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Gene PIK3CA
Variant Q546L
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA Q546L lies within the PIK helical domain of the Pik3ca protein (UniProt.org). Q546L results in increased transformation ability in two different cell lines in culture (PMID: 29533785), and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA Q546L

PIK3CA mutant PIK3CA exon10 PIK3CA Q546X PIK3CA Q546L

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Transcript NM_006218.4
gDNA chr3:g.179218307A>T
cDNA c.1637A>T
Protein p.Q546L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179218307A>T c.1637A>T p.Q546L RefSeq GRCh38/hg38
NM_006218 chr3:g.179218307A>T c.1637A>T p.Q546L RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179218307A>T c.1637A>T p.Q546L RefSeq GRCh38/hg38
XM_006713658 chr3:g.179218307A>T c.1637A>T p.Q546L RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179218307A>T c.1637A>T p.Q546L RefSeq GRCh38/hg38
XM_011512894 chr3:g.179218307A>T c.1637A>T p.Q546L RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218307A>T c.1637A>T p.Q546L RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179218307A>T c.1637A>T p.Q546L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries