STK11 D53Gfs*110
Gene Variant Detail

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Gene STK11
Variant D53Gfs*110
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 D53Gfs*110 indicates a shift in the reading frame starting at amino acid 53 and terminating 110 residues downstream causing a premature truncation of the 433 amino acid Stk11 protein (UniProt.org). D53Gfs*110 has not been characterized however, due to the effects of other truncation mutations downstream of D53 (PMID: 23612973), is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 D53Gfs*110

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Transcript NM_000455.5
gDNA chr19:g.1207070dupG
cDNA c.157dupG
Protein p.D53Gfs*110
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005259618.3 chr19:g.1207070dupG c.157dupG p.D53Gfs*110 RefSeq GRCh38/hg38
NM_000455.4 chr19:g.1207070dupG c.157dupG p.D53Gfs*110 RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1207070dupG c.157dupG p.D53Gfs*110 RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1207070dupG c.157dupG p.D53Gfs*110 RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1207070dupG c.157dupG p.D53Gfs*110 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
STK11 D53Gfs*110 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor