We’re improving your experience!

×

Starting April 21, you’ll be asked to log in or sign up for a free account after viewing 10 content pages each month.

Don’t worry—creating an account is quick and easy, and it comes with added benefits! Once logged in, you’ll not only continue accessing the content you already enjoy, but you’ll also unlock exclusive features like interactive donut plots for variant protein effects and variant impacts across the gene.

Stay tuned for these updates, and thank you for being part of our community!

CTNNB1 H36Y - Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene CTNNB1
Variant H36Y
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions CTNNB1 H36Y does not lie within any known functional domains of the Ctnnb1 protein (UniProt.org). H36Y is predicted to confer a gain of function to the Ctnnb1 protein as demonstrated by nuclear accumulation of Ctnnb1 (PMID: 11276007, PMID: 17163846).
Associated Drug Resistance
Category Variants Paths

CTNNB1 mutant CTNNB1 act mut CTNNB1 H36Y

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_001098210.2
gDNA chr3:g.41224618C>T
cDNA c.106C>T
Protein p.H36Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024453356.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_047447483.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
NM_001904.3 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_006712985.2 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
NM_001098209.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_006712985.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_047447480.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_047447479.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
NM_001098210.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
NM_001098209 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
NM_001098210 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
NM_001904.4 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
NM_001098210.2 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_047447481.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_017005738.2 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_024453357.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_017005738 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
NM_001904 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_024453358.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_024453356.2 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_047447477.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_047447478.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
NM_001098209.2 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_006712985 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_017005738.1 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38
XM_005264886 chr3:g.41224618C>T c.106C>T p.H36Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References