TP53 I195M
Gene Variant Detail

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Gene TP53
Variant I195M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 I195M lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). I195M has been identified in the scientific literature (PMID: 26870891), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 I195M

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Transcript NM_000546.6
gDNA chr17:g.7674946G>C
cDNA c.585C>G
Protein p.I195M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.5 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674946G>C c.585C>G p.I195M RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries