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Gene TP53
Variant C176W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 C176W lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). C176W is associated with decreased induction of PUMA, BAX and p21 expression in a patient sample in cell culture (PMID: 19850740), but has not been fully biochemically characterized and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 C176W

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Transcript NM_000546.6
gDNA chr17:g.7675084G>C
cDNA c.528C>G
Protein p.C176W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.6 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675084G>C c.528C>G p.C176W RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries