TP53 K132T
Gene Variant Detail

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Gene TP53
Variant K132T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 K132T lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). K132T has been identified in sequencing studies (PMID: 26373574, PMID: 25287991), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 K132T

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Transcript NM_000546.6
gDNA chr17:g.7675217T>G
cDNA c.395A>C
Protein p.K132T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407262.1 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001276698.1 chr17:g.7673748T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001276697.3 chr17:g.7673748T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001276697.1 chr17:g.7673748T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001276698.3 chr17:g.7673748T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001276699.3 chr17:g.7673748T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001276699.1 chr17:g.7673748T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675217T>G c.395A>C p.K132T RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References