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| Gene | HRAS |
| Variant | G13dup |
| Impact List | duplication |
| Protein Effect | unknown |
| Gene Variant Descriptions | HRAS G13dup indicates the insertion of the duplicate amino acid, glycine (G)-13, in a GTP-binding region of the Hras protein (UniProt.org). G13dup has been identified in the scientific literature (PMID: 39748775), but has not been biochemically characterized and therefore, its effect on Hras protein function is unknown (PubMed, Mar 2026). |
| Associated Drug Resistance | |
| Category Variants Paths |
HRAS mutant HRAS G13dup |
| Transcript | NM_005343 |
| gDNA | chr11:g.534284_534286dupACC |
| cDNA | c.38_40dupGTG |
| Protein | p.G13dup |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| NM_176795 | chr11:g.534284_534286dupACC | c.38_40dupGTG | p.G13dup | RefSeq | GRCh38/hg38 |
| NM_005343 | chr11:g.534284_534286dupACC | c.38_40dupGTG | p.G13dup | RefSeq | GRCh38/hg38 |
| NM_001130442 | chr11:g.534284_534286dupACC | c.38_40dupGTG | p.G13dup | RefSeq | GRCh38/hg38 |
| Molecular Profile | Protein Effect | Treatment Approaches |
|---|---|---|
| HRAS G13dup | unknown |