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Gene TP53
Variant E346*
Impact List nonsense
Protein Effect unknown
Gene Variant Descriptions TP53 E346* results in a premature truncation of the Tp53 protein at amino acid 346 of 393 (UniProt.org). E346* has been identified in sequencing studies (PMID: 17289876, PMID: 28548125), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 E346*

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Transcript NM_000546.6
gDNA chr17:g.7670673C>A
cDNA c.1036G>T
Protein p.E346*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.6 chr17:g.7670673C>A c.1036G>T p.E346* RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670673C>A c.1036G>T p.E346* RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670673C>A c.1036G>T p.E346* RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670673C>A c.1036G>T p.E346* RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670673C>A c.1036G>T p.E346* RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670673C>A c.1036G>T p.E346* RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670673C>A c.1036G>T p.E346* RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References