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Gene TP53
Variant P128fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 P128fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 128 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). P128fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of P128 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 P128fs

TP53 mutant TP53 inact mut TP53 P128fs

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Transcript NM_000546.6
gDNA chr17:g.(7675230_7675231)
cDNA c.(382_381)
Protein p.P128fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114.3 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7675230_7675231) c.(382_381) p.P128fs RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References