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Gene PIK3CA
Variant I1058F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA I1058F does not lie within any known functional domains of the Pik3ca protein (UniProt.org). I1058F has been identified in sequencing studies (PMID: 17062663, PMID: 21266528, PMID: 32958578), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon21 PIK3CA I1058F

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Transcript NM_006218.4
gDNA chr3:g.179234329A>T
cDNA c.3172A>T
Protein p.I1058F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.4 chr3:g.179234329A>T c.3172A>T p.I1058F RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179234329A>T c.3172A>T p.I1058F RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179234329A>T c.3172A>T p.I1058F RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179234329A>T c.3172A>T p.I1058F RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179234329A>T c.3172A>T p.I1058F RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References