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Gene PIK3CA
Variant I1058L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA I1058L does not lie within any known functional domains of the Pik3ca protein (UniProt.org). I1058L has been identified in sequencing studies (PMID: 32958578), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon21 PIK3CA I1058L

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Transcript NM_006218.4
gDNA chr3:g.179234329A>C
cDNA c.3172A>C
Protein p.I1058L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179234329A>C c.3172A>C p.I1058L RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179234329A>C c.3172A>C p.I1058L RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179234329A>C c.3172A>C p.I1058L RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179234329A>C c.3172A>C p.I1058L RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179234329A>C c.3172A>C p.I1058L RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries