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Gene TP53
Variant K139fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 K139fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 139 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). K139fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of K139 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 K139fs

TP53 mutant TP53 inact mut TP53 K139fs

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Transcript NM_000546.6
gDNA chr17:g.(7675197_7675198)
cDNA c.(415_414)
Protein p.K139fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.3 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7675197_7675198) c.(415_414) p.K139fs RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References