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Gene | PTEN |
Variant | D115Y |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | PTEN D115Y lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). D115Y has not been characterized in the scientific literature and therefore, its effect on Pten protein function is unknown (PubMed, Jun 2024). |
Associated Drug Resistance | |
Category Variants Paths |
PTEN mutant PTEN D115Y |
Transcript | NM_000314.8 |
gDNA | chr10:g.87933102G>T |
cDNA | c.343G>T |
Protein | p.D115Y |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_000314.8 | chr10:g.87933102G>T | c.343G>T | p.D115Y | RefSeq | GRCh38/hg38 |
NM_001304718.2 | chr10:g.87961026G>T | c.343G>T | p.D115Y | RefSeq | GRCh38/hg38 |
NM_001304718 | chr10:g.87961026G>T | c.343G>T | p.D115Y | RefSeq | GRCh38/hg38 |
NM_001304718.1 | chr10:g.87961026G>T | c.343G>T | p.D115Y | RefSeq | GRCh38/hg38 |
NM_000314 | chr10:g.87933102G>T | c.343G>T | p.D115Y | RefSeq | GRCh38/hg38 |
NM_000314.6 | chr10:g.87933102G>T | c.343G>T | p.D115Y | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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