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Gene FLT3
Variant R834_D835del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions FLT3 R834_D835del results in the deletion of two amino acids in the protein kinase domain of the Flt3 protein from amino acids 834 to 835 (UniProt.org). R834_D835del has been identified in sequencing studies (PMID: 31471587, PMID: 33149267), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 R834_D835del

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Transcript NM_004119.3
gDNA chr13:g.28018504_28018509delTCTCGA
cDNA c.2500_2505delCGAGAT
Protein p.R834_D835del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018504_28018509delTCTCGA c.2500_2505delCGAGAT p.R834_D835del RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018504_28018509delTCTCGA c.2500_2505delCGAGAT p.R834_D835del RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References