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| Gene | FLT3 |
| Variant | R834_D835del |
| Impact List | deletion |
| Protein Effect | unknown |
| Gene Variant Descriptions | FLT3 R834_D835del results in the deletion of two amino acids in the protein kinase domain of the Flt3 protein from amino acids 834 to 835 (UniProt.org). R834_D835del has been identified in sequencing studies (PMID: 31471587, PMID: 33149267), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, May 2025). |
| Associated Drug Resistance | |
| Category Variants Paths |
FLT3 mutant FLT3 exon20 FLT3 R834_D835del |
| Transcript | NM_004119.3 |
| gDNA | chr13:g.28018504_28018509delTCTCGA |
| cDNA | c.2500_2505delCGAGAT |
| Protein | p.R834_D835del |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| NM_004119.2 | chr13:g.28018504_28018509delTCTCGA | c.2500_2505delCGAGAT | p.R834_D835del | RefSeq | GRCh38/hg38 |
| NM_004119.3 | chr13:g.28018504_28018509delTCTCGA | c.2500_2505delCGAGAT | p.R834_D835del | RefSeq | GRCh38/hg38 |
| Molecular Profile | Protein Effect | Treatment Approaches |
|---|---|---|
| FLT3 R834_D835del | unknown |