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Gene TP53
Variant I162F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 I162F lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). I162F results in a reduced induction of p21 upon irradiation of patient cells (PMID: 21115975), and leads to increased Tp53 protein stability, but upregulation of miR-18a, cell proliferation, and decrease in ER-alpha expression similar to wild-type Tp53 in a Tp53-null cell line in culture (PMID: 24975878), and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 I162F

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Transcript NM_000546.6
gDNA chr17:g.7675128T>A
cDNA c.484A>T
Protein p.I162F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.3 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675128T>A c.484A>T p.I162F RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References