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NRAS I24N - Gene Variant Detail

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Gene NRAS
Variant I24N
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS I24N lies within the G domain of the Nras protein (PMID: 17384584). I24N results in autoactivation of Sos comparable to wild-type Nras under an autoinhibitory-free condition of Sos, but leads to deregulation of Sos activation under an autoinhibitory condition of Sos in an in vitro assay (PMID: 32753483), and results in increased GTP-bound Nras and activation of downstream signaling in cell culture, demonstrated by increased phosphorylation of Mek, and impaired cell migration in a zebrafish model (PMID: 21263000), and therefore, is predicted to lead to a loss of Nras protein function.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS I24N

NRAS mutant NRAS exon2 NRAS I24N

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Transcript NM_002524.5
gDNA chr1:g.114716090A>T
cDNA c.71T>A
Protein p.I24N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114716090A>T c.71T>A p.I24N RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716090A>T c.71T>A p.I24N RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References