PTEN P339L
Gene Variant Detail

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Gene PTEN
Variant P339L
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN P339L lies within the C2 tensin-type domain of the Pten protein (UniProt.org). P339L fails to suppress E2f1-mediated transcription in cultured cells (PMID: 29108454), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN P339L

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Transcript NM_000314.8
gDNA chr10:g.87961108C>T
cDNA c.1016C>T
Protein p.P339L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87961108C>T c.1016C>T p.P339L RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87961108C>T c.1016C>T p.P339L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References