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Gene FLT3
Variant E858Kfs*29
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions FLT3 E858Kfs*29 indicates a shift in the reading frame starting at amino acid 858 and terminating 29 residues downstream causing a premature truncation of the 993 amino acid Flt3 protein (UniProt.org). E858Kfs*29 has not been characterized in the scientific literature and therefore, its effect on Flt3 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon21 FLT3 E858Kfs*29

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Transcript NM_004119.3
gDNA chr13:g.28015671delC
cDNA c.2572delG
Protein p.E858Kfs*29
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28015671delC c.2572delG p.E858Kfs*29 RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28015671delC c.2572delG p.E858Kfs*29 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FLT3 E858Kfs*29 unknown