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Gene RAD51B
Variant V207L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51B V207L does not lie within any known functional domains of the Rad51b protein (UniProt.org). V207L has been identified in sequencing studies (PMID: 26261251, PMID: 32659497), but has not been biochemically characterized and therefore, its effect on Rad51b protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

RAD51B mutant RAD51B V207L

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Transcript NM_133509.5
gDNA chr14:g.67887067G>C
cDNA c.619G>C
Protein p.V207L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011537050.3 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321810.1 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321812.1 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321821.1 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321818.1 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_133509.5 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321819.1 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321821.2 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321818.2 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_002877.6 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321819.1 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_133510.4 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_133509.3 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321814.1 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321810.2 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_133510.3 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321809.1 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
XM_017021545.2 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_002877.5 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321814.2 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321812.1 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38
NM_001321809.2 chr14:g.67887067G>C c.619G>C p.V207L RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51B mutant ovary serous adenocarcinoma predicted - sensitive Cediranib + Olaparib Clinical Study - Cohort Actionable In a Phase II trial, Cediranib (AZD-2171) and Lynparza (olaparib) treatment was well tolerated, and resulted in an objective response (OR) of 9% (all partial), a 16-week progression-free survival (PFS) of 47%, and a disease control rate (DCR) of 68% in heavily pretreated high-grade serous ovarian cancer patients (n=34), and a median PFS of 4.8 months in patients (n=14) harboring mutations in either BRCA1, BRCA2, or RAD51B (PMID: 32444417; NCT02681237). 32444417