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Gene ROS1
Variant S1626Vfs*7
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ROS1 S1626Vfs*7 indicates a shift in the reading frame starting at amino acid 1626 and terminating 7 residues downstream causing a premature truncation of the 2347 amino acid Ros1 protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), S1626Vfs*7 is predicted to lead to a loss of Ros1 protein function.
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 inact mut ROS1 S1626Vfs*7

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Transcript NM_002944.3
gDNA chr6:g.117341426_117341429delACAG
cDNA c.4876_4879delTCTG
Protein p.S1626Vfs*7
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.2 chr6:g.117341426_117341429delACAG c.4876_4879delTCTG p.S1626Vfs*7 RefSeq GRCh38/hg38
XM_017011173.2 chr6:g.117341296_117341297insTTGGGGGGGGGGGGAC c.4875_4876insGTCCCCCCCCCCCCAA p.S1626Vfs*7 RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117341426_117341429delACAG c.4876_4879delTCTG p.S1626Vfs*7 RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
ROS1 S1626Vfs*7 loss of function - predicted