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Gene TP53
Variant V197M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 V197M lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). V197M has been identified in the scientific literature (PMID: 24038938, PMID: 31889631, PMID: 35181986), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 V197M

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Transcript NM_000546.6
gDNA chr17:g.7674942C>T
cDNA c.589G>A
Protein p.V197M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114.3 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674942C>T c.589G>A p.V197M RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries