Gene Variant Detail

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Gene HRAS
Variant A59I
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS A59I lies within a GTP binding region of the Hras protein (UniProt.org). A59I demonstrates nucleotide affinity and exchange rate similar to wild-type protein, but results in reduced GTPase activity and decreased transforming potential in culture (PMID: 3043178).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS inact mut HRAS A59I

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Transcript NM_005343.4
gDNA chr11:g.533880_533881delGCinsAT
cDNA c.175_176delGCinsAT
Protein p.A59I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533880_533881delGCinsAT c.175_176delGCinsAT p.A59I RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533880_533881delGCinsAT c.175_176delGCinsAT p.A59I RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533880_533881delGCinsAT c.175_176delGCinsAT p.A59I RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533880_533881delGCinsAT c.175_176delGCinsAT p.A59I RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533880_533881delGCinsAT c.175_176delGCinsAT p.A59I RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533880_533881delGCinsAT c.175_176delGCinsAT p.A59I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
HRAS A59I loss of function