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Gene HRAS
Variant V14M
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions HRAS V14M lies within the GTP binding domain of the Hras protein (UniProt.org). V14M results in increased nucleotide binding affinity and accelerated nucleotide exchange rate in in vitro assays, but demonstrates transformation potential similar to wild-type protein in culture (PMID: 3043178), and therefore, is predicted to lead to a gain of Hras protein function.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS V14M

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Transcript NM_005343.4
gDNA chr11:g.534283C>T
cDNA c.40G>A
Protein p.V14M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442.3 chr11:g.534283C>T c.40G>A p.V14M RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534283C>T c.40G>A p.V14M RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534283C>T c.40G>A p.V14M RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534283C>T c.40G>A p.V14M RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534283C>T c.40G>A p.V14M RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534283C>T c.40G>A p.V14M RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References