TP53 R283del
Gene Variant Detail

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Gene TP53
Variant R283del
Impact List deletion
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 R283del (also reported as R282del) results in the deletion of an amino acid in the DNA-binding domain of the Tp53 protein at amino acid 283 (PMID: 22713868). R283del results in loss of Tp53-mediated transcriptional activation in cell culture (PMID: 14690015), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 R283del

TP53 mutant TP53 inact mut TP53 R283del

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Transcript NM_000546.6
gDNA chr17:g.7673771_7673773delGCG
cDNA c.847_849delCGC
Protein p.R283delR
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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