Gene Variant Detail

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Gene HRAS
Variant A66G
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions HRAS A66G does not lie within any known functional domains of the Hras protein (UniProt.org). A66G results in intrinsic and GAP-stimulated GTPase activity comparable to wild-type Hras in in vitro assays (PMID: 1730690), and therefore, is predicted to have no effect on Hras protein function.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS A66G

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Transcript NM_005343.4
gDNA chr11:g.533859G>C
cDNA c.197C>G
Protein p.A66G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533859G>C c.197C>G p.A66G RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533859G>C c.197C>G p.A66G RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533859G>C c.197C>G p.A66G RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533859G>C c.197C>G p.A66G RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533859G>C c.197C>G p.A66G RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533859G>C c.197C>G p.A66G RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
HRAS A66G no effect - predicted