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Gene HRAS
Variant E62A
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions HRAS E62A lies within the GTP binding domain of the Hras protein (PMID: 21779495). E62A results in intrinsic and GAP-stimulated GTPase activity comparable to wild-type Hras in in vitro assays (PMID: 1730690), and therefore, is predicted to have no effect on Hras protein function.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS E62A

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Transcript NM_005343.4
gDNA chr11:g.533871T>G
cDNA c.185A>C
Protein p.E62A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533871T>G c.185A>C p.E62A RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533871T>G c.185A>C p.E62A RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533871T>G c.185A>C p.E62A RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533871T>G c.185A>C p.E62A RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533871T>G c.185A>C p.E62A RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533871T>G c.185A>C p.E62A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries