Gene Variant Detail

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Gene HRAS
Variant Y64F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions HRAS Y64F does not lie within any known functional domains of the Hras protein (UniProt.org). Y64F results in slightly decreased intrinsic and GAP-stimulated GTPase activity in in vitro assays, but maintains transforming activity in cultured cells (PMID: 1730690), and therefore, its effect on Hras protein function is unknown.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS Y64F

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Transcript NM_005343.4
gDNA chr11:g.533865T>A
cDNA c.191A>T
Protein p.Y64F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533865T>A c.191A>T p.Y64F RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533865T>A c.191A>T p.Y64F RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533865T>A c.191A>T p.Y64F RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533865T>A c.191A>T p.Y64F RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533865T>A c.191A>T p.Y64F RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533865T>A c.191A>T p.Y64F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
HRAS Y64F unknown