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Gene | HRAS |
Variant | Y64Q |
Impact List | missense |
Protein Effect | loss of function |
Gene Variant Descriptions | HRAS Y64Q does not lie within any known functional domains of the Hras protein (UniProt.org). Y64Q results in a loss of intrinsic and GAP-stimulated GTPase activity of Hras in in vitro assays and fails to transform cells in culture (PMID: 1730690). |
Associated Drug Resistance | |
Category Variants Paths |
HRAS mutant HRAS inact mut HRAS Y64Q |
Transcript | NM_005343.4 |
gDNA | chr11:g.533864_533866delTACinsCAA |
cDNA | c.190_192delTACinsCAA |
Protein | p.Y64Q |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001130442.3 | chr11:g.533864_533866delTACinsCAA | c.190_192delTACinsCAA | p.Y64Q | RefSeq | GRCh38/hg38 |
NM_005343.3 | chr11:g.533864_533866delTACinsCAA | c.190_192delTACinsCAA | p.Y64Q | RefSeq | GRCh38/hg38 |
NM_001130442.2 | chr11:g.533864_533866delTACinsCAA | c.190_192delTACinsCAA | p.Y64Q | RefSeq | GRCh38/hg38 |
NM_005343.4 | chr11:g.533864_533866delTACinsCAA | c.190_192delTACinsCAA | p.Y64Q | RefSeq | GRCh38/hg38 |
NM_176795.4 | chr11:g.533864_533866delTACinsCAA | c.190_192delTACinsCAA | p.Y64Q | RefSeq | GRCh38/hg38 |
NM_176795.5 | chr11:g.533864_533866delTACinsCAA | c.190_192delTACinsCAA | p.Y64Q | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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