Gene Variant Detail

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Gene HRAS
Variant Y64Q
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS Y64Q does not lie within any known functional domains of the Hras protein (UniProt.org). Y64Q results in a loss of intrinsic and GAP-stimulated GTPase activity of Hras in in vitro assays and fails to transform cells in culture (PMID: 1730690).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS inact mut HRAS Y64Q

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Transcript NM_005343.4
gDNA chr11:g.533864_533866delTACinsCAA
cDNA c.190_192delTACinsCAA
Protein p.Y64Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533864_533866delTACinsCAA c.190_192delTACinsCAA p.Y64Q RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533864_533866delTACinsCAA c.190_192delTACinsCAA p.Y64Q RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533864_533866delTACinsCAA c.190_192delTACinsCAA p.Y64Q RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533864_533866delTACinsCAA c.190_192delTACinsCAA p.Y64Q RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533864_533866delTACinsCAA c.190_192delTACinsCAA p.Y64Q RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533864_533866delTACinsCAA c.190_192delTACinsCAA p.Y64Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References