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Gene HRAS
Variant Y64W
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS Y64W does not lie within any known functional domains of the Hras protein (UniProt.org). Y64W results in a loss of intrinsic and GAP-stimulated GTPase activity of Hras in in vitro assays and fails to transform cells in culture (PMID: 1730690).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS inact mut HRAS Y64W

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Transcript NM_005343.4
gDNA chr11:g.533864_533865delACinsGG
cDNA c.191_192delACinsGG
Protein p.Y64W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.5 chr11:g.533864_533865delACinsGG c.191_192delACinsGG p.Y64W RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533864_533865delACinsGG c.191_192delACinsGG p.Y64W RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533864_533865delACinsGG c.191_192delACinsGG p.Y64W RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533864_533865delACinsGG c.191_192delACinsGG p.Y64W RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533864_533865delACinsGG c.191_192delACinsGG p.Y64W RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533864_533865delACinsGG c.191_192delACinsGG p.Y64W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
HRAS Y64W loss of function