ARID1A A345_A349del
Gene Variant Detail

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Gene ARID1A
Variant A345_A349del
Impact List deletion
Protein Effect loss of function
Gene Variant Descriptions ARID1A A345_A349del results in the deletion of five amino acids of the Arid1a protein from amino acid 345 to 349 (UniProt.org). A345_A349del (reported as A344_A348del) leads to a loss of Arid1a protein function as indicated by reduced Cdkn1a expression and uninhibited cell growth in culture (PMID: 23097632).
Associated Drug Resistance
Category Variants Paths

ARID1A mutant ARID1A inact mut ARID1A A345_A349del

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Transcript NM_006015.6
gDNA chr1:g.26697436_26697450del15
cDNA c.1033_1047del15
Protein p.A345_A349delAAAAA
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006015.6 chr1:g.26697436_26697450del15 c.1033_1047del15 p.A345_A349delAAAAA RefSeq GRCh38/hg38
NM_139135.3 chr1:g.26697436_26697450del15 c.1033_1047del15 p.A345_A349del RefSeq GRCh38/hg38
NM_006015.5 chr1:g.26697436_26697450del15 c.1033_1047del15 p.A345_A349del RefSeq GRCh38/hg38
NM_139135.4 chr1:g.26697436_26697450del15 c.1033_1047del15 p.A345_A349delAAAAA RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References