Gene Variant Detail

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Gene CTNNB1
Variant T42fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions CTNNB1 T42fs results in a change in the amino acid sequence of the Ctnnb1 protein beginning at aa 42 of 781, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of all known functional domains (UniProt.org), T42fs is predicted to confer a loss of function to the Ctnnb1 protein.
Associated Drug Resistance
Category Variants Paths

CTNNB1 mutant CTNNB1 inact mut CTNNB1 T42fs

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Transcript NM_001098210.2
gDNA chr3:g.(41224635_41224636)
cDNA c.(124_123)
Protein p.T42fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001098209 chr3:g.41224637_41224638delCA c.125_126delCA p.T42fs*7 RefSeq GRCh38/hg38
XM_005264886 chr3:g.41224637_41224638delCA c.125_126delCA p.T42fs*7 RefSeq GRCh38/hg38
XM_024453358.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_017005738 chr3:g.41224637_41224638delCA c.125_126delCA p.T42fs*7 RefSeq GRCh38/hg38
NM_001904 chr3:g.41224637_41224638delCA c.125_126delCA p.T42fs*7 RefSeq GRCh38/hg38
XM_024453356.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
NM_001098209.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_047447477.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_047447481.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_047447480.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_017005738.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_047447483.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
NM_001904.3 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_006712985.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_047447478.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
NM_001098209.2 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
NM_001098210.2 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_006712985.2 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_047447479.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
NM_001098210 chr3:g.41224637_41224638delCA c.125_126delCA p.T42fs*7 RefSeq GRCh38/hg38
XM_017005738.2 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_024453357.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_024453356.2 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
XM_006712985 chr3:g.41224637_41224638delCA c.125_126delCA p.T42fs*7 RefSeq GRCh38/hg38
NM_001098210.1 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38
NM_001904.4 chr3:g.(41224635_41224636) c.(124_123) p.T42fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
CTNNB1 T42fs loss of function - predicted