Gene Variant Detail

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Gene TP53
Variant V31I
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions TP53 V31I lies within the CCAR2 and HRMT1L2-interacting regions and the transcription activation region of the Tp53 protein (UniProt.org). V31I results in colony growth, induction of apoptosis, and transcriptional activity similar to wild-type Tp53 in cultured cells (PMID: 33257846), and therefore, is predicted to have no effect on Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 V31I

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Transcript NM_000546.6
gDNA chr17:g.7676387C>T
cDNA c.91G>A
Protein p.V31I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.3 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7676387C>T c.91G>A p.V31I RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
TP53 V31I no effect - predicted