Gene Variant Detail

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Gene TP53
Variant E11Q
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions TP53 E11Q lies within the CCAR2 and HRMT1L2-interacting regions and the transcription activation region of the Tp53 protein (UniProt.org). E11Q results in colony growth, induction of apoptosis, and transcriptional activity similar to wild-type Tp53 in cultured cells (PMID: 33257846), and therefore, is predicted to have no effect on Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon2 TP53 E11Q

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Transcript NM_000546.6
gDNA chr17:g.7676564C>G
cDNA c.31G>C
Protein p.E11Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.5 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7676564C>G c.31G>C p.E11Q RefSeq GRCh38/hg38

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References