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Gene | TP53 |
Variant | E11Q |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | TP53 E11Q lies within the CCAR2 and HRMT1L2-interacting regions and the transcription activation region of the Tp53 protein (UniProt.org). E11Q results in colony growth, induction of apoptosis, and transcriptional activity similar to wild-type Tp53 in cultured cells (PMID: 33257846), and therefore, is predicted to have no effect on Tp53 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon2 TP53 E11Q |
Transcript | NM_000546.6 |
gDNA | chr17:g.7676564C>G |
cDNA | c.31G>C |
Protein | p.E11Q |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001126114.3 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
NM_001126113.2 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
NM_001126114.2 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7676564C>G | c.31G>C | p.E11Q | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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