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Gene | TP53 |
Variant | S378P |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | TP53 S378P lies within the region of the Tp53 protein involved in repression of DNA binding and interaction with CARM1 (UniProt.org). S378P results in colony growth (PMID: 33257846), p21 binding, regulation of target promoters, and STAT4 mRNA expression similar to wild-type Tp53 in culture (PMID: 24076587), and therefore, is predicted to have no effect on Tp53 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon11 TP53 S378P |
Transcript | NM_000546.6 |
gDNA | chr17:g.7669659A>G |
cDNA | c.1132T>C |
Protein | p.S378P |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_000546.6 | chr17:g.7669659A>G | c.1132T>C | p.S378P | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7669659A>G | c.1132T>C | p.S378P | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7669659A>G | c.1132T>C | p.S378P | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7669659A>G | c.1132T>C | p.S378P | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7669659A>G | c.1132T>C | p.S378P | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7669659A>G | c.1132T>C | p.S378P | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7669659A>G | c.1132T>C | p.S378P | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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