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Gene | TP53 |
Variant | P58R |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | TP53 P58R lies within the CCAR2 and HRMT1L2-interacting regions of the Tp53 protein (UniProt.org). P58R results in colony growth, induction of apoptosis, and transcriptional activity similar to wild-type Tp53 in cultured cells (PMID: 33257846), and therefore, is predicted to have no effect on Tp53 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon4 TP53 P58R |
Transcript | NM_000546.6 |
gDNA | chr17:g.7676196G>C |
cDNA | c.173C>G |
Protein | p.P58R |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |