Gene Variant Detail

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Gene TP53
Variant L323V
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions TP53 L323V lies within the CARM1 and HIPK2-interacting regions of the Tp53 protein (UniProt.org). L323V results in colony growth similar to wild-type Tp53 in cultured cells (PMID: 33257846), and therefore, is predicted to have no effect on Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon9 TP53 L323V

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Transcript NM_000546.6
gDNA chr17:g.7673561G>C
cDNA c.967C>G
Protein p.L323V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.3 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673561G>C c.967C>G p.L323V RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References