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Gene | TP53 |
Variant | T312S |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | TP53 T312S lies within the CARM1 and CCAR2-interacting regions of the Tp53 protein (UniProt.org). T312S results in colony growth, induction of apoptosis, and transcriptional activity similar to wild-type Tp53 in cultured cells (PMID: 33257846), and therefore, is predicted to have no effect on Tp53 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon9 TP53 T312S |
Transcript | NM_000546.6 |
gDNA | chr17:g.7673593G>C |
cDNA | c.935C>G |
Protein | p.T312S |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001126112.3 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
NM_001126114.2 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
NM_001126113.2 | chr17:g.7673593G>C | c.935C>G | p.T312S | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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